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Blood thinners

Clopidogrel

Also sold as: Plavix

Prescription neededBlood thinners
Comes as:Tablet

Usual adult dose

Usual adult dose: 75 mg once a day. After a heart attack or stent, a first dose of 300 to 600 mg may be given in hospital. Do not stop without asking your heart doctor.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • bruising
  • nosebleeds
  • stomach upset
  • diarrhoea

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • black stools or vomiting blood
  • blood in urine
  • bleeding that does not stop
  • sudden weakness or severe headache (bleeding in the brain)

Do not take it, or take care, if

  • Active bleeding (bleeding stomach ulcer, bleeding in the brain)
  • Severe liver disease
  • Before surgery or tooth extraction (tell your doctor or dentist)

Interactions

Medicines that can react with this one.

Serious3 medicinesDo not take these together unless your doctor says so.
  • Esomeprazole

    Esomeprazole reduces the activation of clopidogrel and may weaken its effect.

  • Rivaroxaban

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category B

No risk seen in animal studies, but there are few studies in pregnant women. Usually considered safe when needed.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • purple spots with fever
  • Together they greatly raise the risk of serious bleeding.

  • Warfarin

    Together they greatly raise the risk of serious bleeding.

  • Moderate6 medicinesTake together only with care. Ask your doctor or pharmacist.
    • Apixaban

      Together they raise the risk of bleeding.

    • Aspirin

      Often used together on purpose after a stent, but bleeding risk is higher.

    • Enoxaparin

      Together they raise the risk of bleeding.

    • Ibuprofen

      NSAIDs with clopidogrel raise the risk of stomach bleeding.

    • Lansoprazole

      Lansoprazole may reduce the activation of clopidogrel.

    • Omeprazole

      Omeprazole reduces the activation of clopidogrel; pantoprazole is usually preferred.

    Aspirin
    No prescription needed
    Check with my other medicines

    Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.