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Nausea and vomiting

Metoclopramide

Also sold as: Maxolon, Reglan

Prescription neededNausea and vomiting
Comes as:TabletSyrupInjection

Usual adult dose

Usual adult dose: 10 mg up to 3 times a day. Do not take more than 30 mg in 24 hours or for longer than 5 days. Avoid in children and young people unless a doctor advises.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • drowsiness
  • tiredness
  • restlessness
  • diarrhoea

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • uncontrolled movements of the face
  • tongue
  • eyes or neck (especially in young people)
  • high fever with stiff muscles

Do not take it, or take care, if

  • Bowel blockage, bleeding or tear in the stomach or bowel
  • Epilepsy or Parkinson disease
  • Children under 1 year; use in under-18s only on specialist advice
  • Phaeochromocytoma (adrenal tumour)
  • Depression (use with caution)

Interactions

Medicines that can react with this one.

Serious2 medicinesDo not take these together unless your doctor says so.
  • Haloperidol

    Together they greatly increase the risk of movement disorders and neuroleptic malignant syndrome.

  • Levodopa + Carbidopa

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category B

No risk seen in animal studies, but there are few studies in pregnant women. Usually considered safe when needed.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • depression
  • irregular heartbeat
  • Metoclopramide blocks dopamine and opposes levodopa; avoid in Parkinson disease.

    Moderate3 medicinesTake together only with care. Ask your doctor or pharmacist.
    • Dicycloverine

      They have opposite effects on the gut and can cancel each other out.

    • Hyoscine butylbromide

      They have opposite effects on the gut and can cancel each other out.

    • Sertraline

      The combination can increase the risk of movement problems and serotonin syndrome.

    Minor1 medicineUsually not a problem, but tell your doctor.
    • Fosfomycin

      Metoclopramide can lower fosfomycin levels in the blood and urine.

    Domperidone
  • Ondansetron
  • Check with my other medicines

    Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.