Tenofovir + Lamivudine + Dolutegravir
Usual adult dose
Dose is set by your doctor. Usual adult dose for HIV: one tablet (tenofovir 300 mg, lamivudine 300 mg, dolutegravir 50 mg) once a day, every day, for life. Do not miss doses.
Your doctor may give you a different dose. Children's doses depend on weight.
Side effects
Common
- headache
- trouble sleeping
- nausea
- diarrhoea
- weight gain
Serious — get help
Stop taking it and see a doctor straight away if you notice:
- severe allergic reaction with rash and fever
- yellow eyes or skin
- kidney problems
- low mood or thoughts of self-harm
Do not take it, or take care, if
- Kidney disease (needs dose review)
- Taking rifampicin (dolutegravir dose must be increased by the doctor)
- Hepatitis B (never stop suddenly)
- Known allergy to dolutegravir
Interactions
Medicines that can react with this one.
Serious2 medicinesDo not take these together unless your doctor says so.
- Rifampicin
Rifampicin lowers dolutegravir levels; an extra 50 mg dolutegravir dose is needed during TB treatment.
- Rifampicin + Isoniazid + Pyrazinamide + Ethambutol
Rifampicin lowers dolutegravir levels; an extra dolutegravir dose is needed.
Moderate3 medicinesTake together only with care. Ask your doctor or pharmacist.
- Aluminium hydroxide + Magnesium hydroxide
Antacids block dolutegravir absorption; take the tablet 2 hours before or 6 hours after.
- Ferrous sulfate
Iron reduces dolutegravir absorption unless both are taken with food.
- Metformin
Dolutegravir raises metformin levels; the metformin dose may need lowering.