Sofosbuvir
Also sold as: Sovaldi, Hepcinat
Prescription neededAntivirals
Comes as:Tablet
Usual adult dose
Dose is set by your doctor. Usual adult dose for hepatitis C: 400 mg once a day, always together with another hepatitis C medicine such as daclatasvir, usually for 12 weeks.
Your doctor may give you a different dose. Children's doses depend on weight.
Side effects
Common
- tiredness
- headache
- nausea
- trouble sleeping
Serious — get help
Stop taking it and see a doctor straight away if you notice:
- very slow heartbeat (especially with amiodarone)
- hepatitis B flare in people who also carry hepatitis B
Do not take it, or take care, if
- Taking amiodarone
- Pregnancy (especially when combined with ribavirin)
- Severe kidney disease (ask your doctor)
- Hepatitis B carriers (need monitoring)
Interactions
Medicines that can react with this one.
Serious3 medicinesDo not take these together unless your doctor says so.
- Amiodarone
Sofosbuvir with amiodarone can cause dangerously slow heartbeat; avoid the combination.
- Carbamazepine
Carbamazepine lowers sofosbuvir levels so treatment may fail.
- Rifampicin
Rifampicin lowers sofosbuvir levels so treatment may fail.