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Chest pain and heart rhythm

Amiodarone

Also sold as: Cordarone

Prescription neededChest pain and heart rhythm
Comes as:TabletInjection

Usual adult dose

Dose is set by a heart specialist. Typical: 200 mg three times a day for 1 week, then twice a day for 1 week, then 200 mg once a day or less. Regular thyroid, liver, lung and eye checks are needed.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • nausea
  • sensitivity to sunlight
  • grey-blue skin
  • tiredness
  • tremor

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • breathlessness or cough (lung damage)
  • thyroid problems
  • yellow eyes or skin

Do not take it, or take care, if

  • Slow heartbeat or heart block (without a pacemaker)
  • Thyroid disease
  • Pregnancy and breastfeeding
  • Iodine allergy

Interactions

Medicines that can react with this one.

Serious26 medicinesDo not take these together unless your doctor says so.
  • Amitriptyline

    Both affect heart rhythm; the combination can cause dangerous arrhythmias.

  • Artemether + Lumefantrine

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category D

There is evidence of risk to the baby. Used only in serious situations when safer medicines do not work.

Check with my other medicines
slow or irregular heartbeat
  • vision changes
  • Both prolong the QT interval and can cause dangerous heart rhythms.

  • Azithromycin

    Both can prolong the QT interval and cause dangerous heart rhythms.

  • Chloroquine

    Both prolong the QT interval and can cause dangerous heart rhythms.

  • Chlorpromazine

    Both prolong the QT interval and can cause dangerous heart rhythms.

  • Citalopram

    Both can prolong the QT interval and cause dangerous heart rhythms.

  • Show 20 more
    • Clarithromycin

      Both can prolong the QT interval and cause dangerous heart rhythms.

    • Daclatasvir

      With sofosbuvir-based treatment, amiodarone can cause dangerously slow heartbeat.

    • Digoxin

      Amiodarone raises digoxin levels; the digoxin dose usually needs halving.

    • Dihydroartemisinin + Piperaquine

      Both prolong the QT interval and can cause dangerous heart rhythms.

    • Domperidone

      Both prolong the QT interval; the combination should be avoided.

    • Escitalopram

      Both can prolong the QT interval and cause dangerous heart rhythms.

    • Fluconazole

      Both can prolong the QT interval and cause dangerous heart rhythms.

    • Haloperidol

      Both prolong the QT interval and can cause dangerous heart rhythms.

    • Hydroxychloroquine

      Both prolong the QT interval; together they raise the risk of dangerous heart rhythms.

    • Hydroxyzine

      Both prolong the QT interval; the combination should be avoided.

    • Imipramine

      Both affect heart rhythm; the combination can cause dangerous arrhythmias.

    • Levofloxacin

      Both prolong the QT interval and can cause dangerous heart rhythms.

    • Meglumine antimoniate

      Both can prolong the QT interval and cause dangerous heart rhythms.

    • Moxifloxacin

      Both prolong the QT interval and can cause dangerous heart rhythms.

    • Ondansetron

      Both prolong the QT interval and together raise the risk of dangerous heart rhythms.

    • Quinine

      Both prolong the QT interval and can cause dangerous heart rhythms.

    • Simvastatin

      Amiodarone raises simvastatin levels; do not take more than 20 mg simvastatin a day.

    • Sodium stibogluconate

      Both can prolong the QT interval and cause dangerous heart rhythms.

    • Sofosbuvir

      Amiodarone with sofosbuvir can cause dangerously slow heartbeat.

    • Warfarin

      Amiodarone strongly raises the effect of warfarin; the warfarin dose usually needs lowering and INR checks.

    Moderate3 medicinesTake together only with care. Ask your doctor or pharmacist.
    • Bisoprolol

      Together they can slow the heart too much.

    • Lidocaine

      Amiodarone can raise lidocaine levels and add to effects on heart rhythm.

    • Quetiapine

      Both can prolong the QT interval.

    Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.