Imipramine
Also sold as: Tofranil
Prescription neededAntidepressants
Comes as:Tablet
Usual adult dose
Dose is set by your doctor. For depression it is usually started at 25 mg one to three times a day and raised slowly (often 75 mg to 150 mg a day). Bedwetting in children: only as prescribed by a doctor. An overdose is very dangerous.
Your doctor may give you a different dose. Children's doses depend on weight.
Side effects
Common
- drowsiness
- dry mouth
- constipation
- blurred vision
- sweating
- dizziness on standing up
Serious — get help
Stop taking it and see a doctor straight away if you notice:
- fast or irregular heartbeat
- fainting
- difficulty passing urine
- confusion
- seizures
- thoughts of suicide
Do not take it, or take care, if
- Recent heart attack or heart rhythm problems
- Taking an MAO inhibitor antidepressant
- Narrow-angle glaucoma
- Enlarged prostate or difficulty passing urine (use with caution)
- Epilepsy (use with caution)
- Pregnancy (ask your doctor)
Interactions
Medicines that can react with this one.
Serious2 medicinesDo not take these together unless your doctor says so.
- Amiodarone
Both affect heart rhythm; the combination can cause dangerous arrhythmias.
- Tramadol
Together they raise the risk of seizures and serotonin syndrome.
Moderate2 medicinesTake together only with care. Ask your doctor or pharmacist.
- Clonidine
Imipramine can reduce the blood-pressure-lowering effect of clonidine.
- Fluoxetine
Fluoxetine raises imipramine levels and its side effects.