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Allergy medicines (antihistamines)

Promethazine

Also sold as: Phenergan

Prescription neededAllergy medicines (antihistamines)
Comes as:TabletSyrupInjection

Usual adult dose

Usual adult dose: 10 to 25 mg at night or up to 25 mg twice a day for allergy; 25 mg for nausea or travel sickness. Must not be given to children under 2 years.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • strong drowsiness
  • dry mouth
  • dizziness
  • blurred vision

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • slowed breathing (especially in young children)
  • fits
  • uncontrolled muscle movements
  • severe tissue damage if an injection leaks

Do not take it, or take care, if

  • Children under 2 years (risk of fatal breathing problems)
  • Glaucoma or difficulty passing urine
  • Severe liver disease or epilepsy (use with caution)
  • Do not drive or use machines; avoid alcohol

Interactions

Medicines that can react with this one.

Serious1 medicineDo not take these together unless your doctor says so.
  • Morphine

    Combined use can cause deep sedation and dangerously slowed breathing.

Moderate2 medicinesTake together only with care. Ask your doctor or pharmacist.
  • Diazepam

    Together they cause more drowsiness and slowed breathing.

  • Tramadol

    Increases drowsiness and may raise the risk of fits.

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category C

A risk to the baby cannot be ruled out. Use only if your doctor says the benefit is greater than the risk.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

  • ChlorphenamineNo prescription needed
  • DiphenhydramineNo prescription needed
  • Hydroxyzine
Check with my other medicines

Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.