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Antifungals

Ketoconazole

Also sold as: Nizoral

Prescription neededAntifungals
Comes as:CreamShampooTablet

Usual adult dose

Mostly used on the skin: cream once or twice a day, or shampoo twice a week for 2 to 4 weeks for dandruff. Tablets can damage the liver and are used only if a doctor prescribes them.

Your doctor may give you a different dose. Children's doses depend on weight.

Side effects

Common

  • local irritation or burning
  • dry hair with shampoo
  • nausea and stomach pain with tablets

Serious — get help

Stop taking it and see a doctor straight away if you notice:

  • liver damage with tablets (yellow eyes or skin
  • dark urine)
  • severe allergic reaction

Do not take it, or take care, if

  • Liver disease (tablets)
  • Pregnancy (tablets)
  • Taking simvastatin (tablets)
  • Tablets should not be used for simple skin fungus

Interactions

Medicines that can react with this one.

Serious6 medicinesDo not take these together unless your doctor says so.
  • Apixaban

    Ketoconazole tablets raise apixaban levels and the risk of bleeding; avoid.

  • Domperidone

Pregnancy

  1. A
  2. B
  3. C
  4. D
  5. X

Category C

A risk to the baby cannot be ruled out. Use only if your doctor says the benefit is greater than the risk.

Generic alternatives

Similar medicines your doctor or pharmacist may offer instead.

Ketoconazole raises domperidone levels and can cause dangerous heart rhythms; do not combine.

  • Fluticasone + Salmeterol

    Ketoconazole greatly raises salmeterol and fluticasone levels, risking heart rhythm problems and steroid effects.

  • Rifampicin

    Rifampicin lowers ketoconazole levels so it may not work.

  • Rivaroxaban

    Ketoconazole tablets raise rivaroxaban levels and the risk of bleeding; avoid.

  • Simvastatin

    Ketoconazole tablets greatly raise simvastatin levels and the risk of severe muscle damage.

  • Moderate5 medicinesTake together only with care. Ask your doctor or pharmacist.
    • Budesonide

      Ketoconazole raises budesonide levels and can cause steroid side effects.

    • Famotidine

      Reduced stomach acid lowers absorption of ketoconazole.

    • Omeprazole

      Stomach acid reducers lower absorption of ketoconazole tablets.

    • Solifenacin

      Ketoconazole raises solifenacin levels; the dose should not exceed 5 mg.

    • Warfarin

      Ketoconazole tablets can raise the effect of warfarin; INR should be checked.

    Clotrimazole
    No prescription needed
  • MiconazoleNo prescription needed
  • Fluconazole
  • Check with my other medicines

    Always follow your doctor or pharmacistThis page is general information, not a prescription. Do not start, stop or change a medicine on your own.