Itraconazole
Also sold as: Sporanox, Canditral
Usual adult dose
Usual adult dose: 100 to 200 mg once or twice a day, capsules taken right after a full meal. Length depends on the infection, for example 200 mg a day for 7 days for skin fungus.
Your doctor may give you a different dose. Children's doses depend on weight.
Side effects
Common
- nausea
- stomach pain
- headache
- rash
Serious — get help
Stop taking it and see a doctor straight away if you notice:
- yellow eyes or skin
- swelling of legs or breathlessness (heart failure)
- severe skin rash
- numbness of hands and feet
Do not take it, or take care, if
- Heart failure
- Pregnancy
- Liver disease (use with caution)
- Taking simvastatin
Interactions
Medicines that can react with this one.
Serious5 medicinesDo not take these together unless your doctor says so.
- Alprazolam
Itraconazole greatly raises alprazolam levels; avoid together.
- Atorvastatin
Itraconazole raises atorvastatin levels and the risk of muscle damage.
- Midazolam
Itraconazole greatly raises midazolam levels and prolongs sedation.
- Rifampicin
Rifampicin lowers itraconazole levels so much that it may not work.
- Simvastatin
Itraconazole greatly raises simvastatin levels and the risk of severe muscle damage; do not combine.
Moderate7 medicinesTake together only with care. Ask your doctor or pharmacist.
- Budesonide
Itraconazole raises budesonide levels and can cause steroid side effects.
- Budesonide + Formoterol
Itraconazole raises budesonide levels and can cause steroid side effects.
- Famotidine
Reduced stomach acid lowers absorption of itraconazole capsules.
- Lansoprazole
Reduced stomach acid lowers absorption of itraconazole capsules.
- Loperamide
Itraconazole raises loperamide levels and may increase side effects, including heart rhythm problems.
- Omeprazole
Stomach acid reducers lower absorption of itraconazole capsules.
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- Pantoprazole
Reduced stomach acid lowers absorption of itraconazole capsules.